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Such protocols are intended to identify a small group of women whose evidence of hereditary cancer is sufficiently strong that genetic testing for BRCA1/2 mutations can be considered (e.g., positive predictive value of ≥10%).The purpose of the present analysis is to (1) identify published breast/ovarian cancer family history screening protocols that are endorsed by professional and/or governmental organizations, (2) apply these protocols to the family histories obtained from a population-based cohort of younger women, (3) compute and compare the proportion of women identified as candidates for genetic testing by each of the protocols, and (4) compare the level of agreement between the protocols.
In 30 of the families (including all 12 women with a personal history), one age of onset of cancer was unavailable.
In 14 additional families, two or more ages of onset were missing.
These median values were set, conservatively, to 10 years earlier than the median age of onset reported in the latest data reported by the Surveillance, Epidemiology, and End Results.
In 13 families, one or more ages of onset were specified as a decade.
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