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In other words, there is a relatively high likelihood that a particular mutation in a target sequence will result in antibiotic resistance.This high likelihood translates into a very rapid evolutionary process. The evolution of antibiotic resistance of any previously susceptible bacterial colony to just about any antibiotic is usually realized within a very short period of sustained antibiotic exposure.He is a newlywed who said he has never been cheated on.

The problem is that sometimes one or two or even a few bacteria survive the initial exposure.

This is because they were previously resistant before exposure to the antibiotic.

The de novo evolution of antibiotic resistance is based on the specificity of antibiotic interactions with various protein sequences within a bacterium.

Because of the specificity of such interactions, a very high ratio of mutations are able to interfere with or completely disrupt these specific interactions - and antibiotic resistance is the result.

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