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Relatively new are the 5HT3 agents (Zofran, Kytril).In theory, these agents might not be ideal for emesis related to vestibular imbalance.H3 receptor agonists appear to cause the same result as blockade of H2 receptors.
We also highly recommend the neuropharmacology review article written by Soto et al (2013).
A discussion of drug treatment should start with a discussion of the neurotransmitters used to signal in the vestibular system. Vestibular suppressant and antiemetic drugs are the mainstay of treatment of vertigo.
Serafin and others (1993) reported that histamine increases firing in MVN cells, mediated through the H2 receptor.
H1 receptors are present in guinea pig vestibular nucleus, but they don't seem to be relevant to vertigo, and it does not appear that the therapeutic effects of H1 receptor blockers can be attributed to blockate of H1 (Timmerman, 1994).
Histamine agonists that act on receptor subtypes are also used for treatment of vertigo (e.g. This can sometimes result in a peculiar situation where individuals take both antihistamines and histamine agonists at the same time.